The rupee was trading nearly 10 paise down at 64.21 against dollar in early trade on account of buying of American currency by banks and importers.
Rupee opened 8 paise down at 64.19 against the US currency on Friday.
The local currency on Thursday settled at a fresh two-and-a-half month high of 64.11 a dollar after the US currency took a big knock amid the Fed indicating it will maintain a slow pace of monetary tightening.
Meanwhile, domestic equity markopened flat following mixed global cues. The BSE Sensex was down 106.99 points, or 0.33 per cent, at 32,276.31 in opening trade, while the NSE Nifty index opened 24 points, or 0.24 per cent, down at 9,996.55.
Foreign portfolio investors stood net sellers in domestic equity markets on Thursday and sold shares worth Rs 192.56 crore with gross purchases and gross sales of Rs 5456.65 crore and Rs 5649.21 crore, respectively.